GLOSSARY TERM

Homeostasis

Homeostasis is the fundamental biological principle of maintaining a stable, relatively constant internal environment despite changes in external conditions. This dynamic equilibrium is essential for the survival of all living organisms. The body monitors various parameters—including blood glucose levels, pH, temperature, and energy stores—and employs feedback loops to correct any deviations from the 'set point' or ideal range.

The hypothalamus is the primary coordinator of homeostasis in the human body. When it comes to weight management, the body's homeostatic mechanisms often work against weight loss, as the brain perceives a reduction in fat stores as a threat to stability. This leads to the activation of the survival shift. Achieving lasting fat loss requires 'renegotiating' this homeostatic set point through phased nutritional strategies and hormonal support, allowing the body to accept a lower weight as its new stable state.

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Clark, R. (2026). Homeostasis. In *CFP Weight Loss glossary*. https://glossary.cfpweightloss.com/homeostasis
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Russell Clark, FNP-C, APRN
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Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

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