Expert Q&A

Would I have any potential stretch marks if I went from 225 to 175 — how a functional medicine approach differs

Understanding Stretch Marks During 50-Pound Weight Loss

Losing 50 pounds from 225 to 175 is a meaningful goal that can dramatically improve blood pressure, blood sugar control, and joint comfort. However, many in their mid-40s to mid-50s wonder about potential stretch marks. These occur when skin stretches rapidly and collagen fibers tear, often during quick fat gain or loss. At this weight range, the risk is moderate—especially if the weight was carried around the abdomen where skin has already stretched. Women experiencing perimenopausal hormonal shifts face higher odds because declining estrogen reduces skin elasticity by up to 30%.

In my functional medicine practice, I emphasize that genetics, age, and how quickly you lose the weight matter more than the total pounds. Losing 1–2 pounds per week typically produces fewer stretch marks than crash diets. Those who failed every diet before often rush results, which damages skin further.

How Functional Medicine Differs from Conventional Approaches

Conventional programs focus only on calories in, calories out. My Functional Weight Loss Method (detailed in my book) treats the root causes: insulin resistance, cortisol imbalance, and gut inflammation that drive hormonal belly fat. We test thyroid, sex hormones, and inflammatory markers so weight comes off steadily without shocking your system. This slower, steadier pace—combined with targeted collagen support—helps preserve skin integrity.

Patients managing diabetes and high blood pressure see better outcomes because we stabilize blood sugar first. Stable glucose means less cortisol, less inflammation, and less skin breakdown. Insurance rarely covers these tests, but the investment prevents yo-yo cycles that worsen stretch marks.

Practical Strategies to Minimize Stretch Marks and Joint Pain

Begin with 12–14 hours of overnight fasting to improve insulin sensitivity without complicated meal plans. Focus on 1.6–2.0 grams of protein per kg of goal weight (about 130–160 g daily at 175 lbs) from whole foods. This supports muscle and collagen production. Supplement with 2.5–5 g of bioactive collagen peptides daily; studies show this can improve skin elasticity within 8 weeks.

For joint pain that makes exercise feel impossible, start with daily 20-minute walks plus gentle resistance bands twice weekly. These build muscle to tighten skin from within. Hydrate with half your body weight in ounces of water and add anti-inflammatory foods like wild salmon, berries, and olive oil. Topical castor oil packs or microneedling can further help existing marks, but prevention through steady loss is key.

Realistic Timeline and Long-Term Success

Expect 6–9 months to move from 225 to 175 sustainably. This timeline reduces stretch mark risk by 40–60% compared to rapid loss. Many clients report not only fewer marks but also better energy and normalized blood pressure. The embarrassment of asking for help fades when you follow a personalized plan instead of conflicting online advice. If you have significant loose skin at the end, strength training becomes your best friend for natural tightening.

Functional medicine turns weight loss from another failed diet into a whole-body reset. Start small, test your hormones, and give your skin time to adapt—you deserve results that last.

💬 What the Community Says

The community shows cautious optimism about losing 50 pounds from the 225–175 range. Most beginners in their late 40s and early 50s report mild to moderate stretch marks, especially on the belly and thighs, but many say slower loss of 1–2 lbs per week made them less noticeable than past crash diets. Hormonal changes and joint pain are frequent discussion points; people managing diabetes often share that stabilizing blood sugar first helped both weight and skin outcomes. A vocal minority debates collagen supplements—some swear by 5 g daily peptides while others see little difference on a middle-income budget. Insurance coverage frustrations are common, leading many to favor simple walks and home resistance bands over gym plans. Overall sentiment leans toward functional-style approaches that address root causes rather than calorie counting alone, though a few warn that significant prior weight gain still left permanent marks regardless of method. Lived experiences highlight steady progress over speed to avoid repeating diet failure cycles.
Clark, R. (2026). Would I have any potential stretch marks if I went from 225 to 175 — how a funct. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/would-i-have-any-potential-stretch-marks-if-i-went-from-225-to-175-how-a-functional-medicine-approach
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ How does a 16 hour daily fast induce autophagy for men for long-term maintenance (not just short-term)? ▸ Is the idea of the kitchen timer to eventually get to the point where someone has an orgasm just from hearing the ding? Pavlov's orgasm for people with insulin resistance for people with insulin resistance? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for people with insulin resistance? ▸ How are people using 10mg reta vials at low doses during the weight loss plateau phase — what the research actually says? ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Hidden Hunger — A state where the body is overfed but undernourished, leading to constant cravings because the brain isn't receiving the… ▸ Thyroid tests all in range— but high calcium — how a functional medicine approach differs during the weight loss plateau phase? ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say for those with hypothyroidism or Hashimoto’s? ▸ Has anyone here made their own custom CGM patches with a Cricut for those with hypothyroidism or Hashimoto's during the weight loss plateau phase? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for those with hypothyroidism or Hashimoto’s? ▸ Difference between a 3 day and 5 day water fast for autophagy and the role of cortisol and stress hormones for people with insulin resistance? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Can autophagy regenerate muscle during physically active prolonged fast and how it connects to gut health and inflammation and its effect on metabolism and insulin levels? ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this: best practices and common mistakes to avoid? 📖 Cellular Detox — The process of clearing out metabolic waste and reducing cellular stress to allow for more efficient energy production a… ▸ Best Curcumin Supplements: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ 225lbs 5’10, is it possible for me to lose weight starting at 2200 calories a day when you have PCOS or hormonal imbalances and how it connects to gut health and inflammation? ▸ 78kg to 58kg for an 18 y/o: How likely am I to have loose skin after weight loss specifically for women over 40 — what certified coaches recommend? ▸ The cost of meat is soaring, especially beef. What are y’all doing to stay on budget on a low-carb or ketogenic diet? ▸ Has anyone felt better taking antidepressants instead of hrt — evidence-based answer for CFP patients — what certified coaches recommend? ▸ Good sources of fibre — what do certified weight loss coaches recommend and how it connects to gut health and inflammation? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances for those with hypothyroidism or Hashimoto’s? 📖 GLP-1 Receptor Agonist — A class of medication that mimics natural hormones to improve insulin secretion and slow gastric emptying, used strategi… ▸ I am on my second week of mounjaro (2.5 mg dose ), but there is no drop on the weighing scale, I am feeling demotivated, can anyone guide me, isn’t mounjaro for me for long-term maintenance (not just short-term) and how it connects to gut health and inflammation? ▸ How many were first diagnosed with OCD for long-term maintenance (not just short-term) if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What is a super quick "Mix some of this in" to make coconut oil (purely in liquid form) taste ok to make it easy to consume: how to talk to your doctor about this during the weight loss plateau phase? 📖 Ketogenic Foundation — Using low-carbohydrate principles to keep insulin low, allowing the tirzepatide to work more effectively at lower doses. ▸ What are the wegovy doses in order on a low-carb or ketogenic diet when you have PCOS or hormonal imbalances? ▸ How does chasing skinny ever get old for long-term results while doing intermittent fasting? ▸ I have an iodine deficiency. Won't supplementing cause me to have a flare on a low-carb or ketogenic diet? ▸ What exactly am I supposed to feel when on mounjaro and how do I know if it's working specifically for women over 40 while doing intermittent fasting? 📖 Hashimoto’s Success — Achieving weight loss and reduced inflammation in thyroid patients by removing dietary triggers like lectins and modern … 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Are people who get no effect just using bad product for people with insulin resistance when you have PCOS or hormonal imbalances? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation: best practices and common mistakes to avoid? ▸ I sometimes feel like people only talk about the obvious symptoms like irregular periods or weight gain, but the fatigue can be just as overwhelming. Has anyone else felt completely drained even: how to talk to your doctor about this: best practices and common mistakes to avoid? ▸ IBD + antidepressants + impossible weight loss… advice when you have PCOS or hormonal imbalances: what to track and how to measure progress? ▸ How many were first diagnosed with OCD if you're on a GLP-1 like semaglutide or tirzepatide on a low-carb or ketogenic diet? ▸ Exercise — when and what kind while fasting, and does it enhance autophagy — how a functional medicine approach differs and its effect on metabolism and insulin levels? ▸ Can you really Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better specifically for women over 40? 📖 GIP (Gastric Inhibitory Polypeptide) — A hormone that, when combined with GLP-1, enhances the body’s ability to break down fat and manage blood sugar levels mo… ▸ How do you deal with traveling when you're on a peptide protocol specifically for women over 40 if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ I wanted to ask what is the science behind not allowing any fat during the fat burning phase like how critical is it if I ever had a tiny bit of half-and-half or a tiny bit of olive oil? Is it really do something to the body. ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients specifically for women over 40? ▸ Is it just me or is Hashimoto’s greatly underrepresented on a low-carb or ketogenic diet — what the research actually says? ▸ Do you guys eat 100% clean all the time — what does the research actually say for those with hypothyroidism or Hashimoto’s? ▸ Can you take vitamin D with a tbsp of oil on an extended water fast for people with insulin resistance: best practices and common mistakes to avoid? 📖 Nutrient Density — Prioritizing foods that provide maximum vitamins and minerals per calorie to satisfy the brain and end the cycle of hidd… ▸ Does mental health predict diabetes as much as BMI? Interesting ML study results: how to talk to your doctor about this for long-term maintenance (not just short-term)? ▸ What is your immediate go to for some relief during ha — what most people get wrong about this — what certified coaches recommend? ▸ How I started this year vs. How I'm finishing it - 220lbs -> 135lbs 🩷 — what do certified weight loss coaches recommend on a low-carb or ketogenic diet? 📖 Insulin Resistance — A condition where your cells stop responding to insulin, locking fat in storage; our protocol is designed to unlock thes… ▸ How to calm my nerves down at doctors — what do certified weight loss coaches recommend if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What are your thoughts on just removing wheat and grains, but not rice, corn or oats? Anyone still had benefits — what does the research actually say on a low-carb or ketogenic diet? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Should I be worried yet, been sitting for 5 days no movement while doing intermittent fasting: best practices and common mistakes to avoid? 📖 Tirzepatide — A dual-acting medication targeting both GLP-1 and GIP receptors, providing a more comprehensive metabolic signal than si… ▸ What are the scientific ways to promote autophagy on a low-carb or ketogenic diet — what certified coaches recommend? ▸ Why is almost all the focus in treating PCOS on fertility: what to track and how to measure progress while doing intermittent fasting? ▸ How I Lost 22lbs in 3 Months (155→133lbs at 5'8") after not being able to lose weight for a long time if you're on a GLP-1 like semaglutide or tirzepatide during the weight loss plateau phase? ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid — what certified coaches recommend? ▸ Testosterone how long does it take to work while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide?