Expert Q&A

Where to go from here? I lost 13kg on mounjaro, but I am doing the rest naturally. Advice? :) and the role of cortisol and stress hormones

Congratulations on Your 13kg Loss – Now Protect It Naturally

Losing 13kg on Mounjaro is a major win, especially with your hormonal changes and joint pain. The real challenge begins now: transitioning to sustainable natural weight loss without medication. In my book The CFP Method, I emphasize building metabolic resilience through simple daily habits that address root causes like stress, insulin resistance, and inflammation. Since insurance rarely covers these programs and time is limited, we'll focus on beginner-friendly strategies that fit middle-income lifestyles and manage diabetes and blood pressure alongside weight.

Practical Next Steps for Natural Maintenance

Start with a 12-week stabilization phase. Reduce processed carbs to under 100g daily while increasing protein to 1.6g per kg of body weight—this preserves muscle lost during rapid GLP-1 phases. Walk 30 minutes daily in two 15-minute sessions; this low-impact movement eases joint pain and improves blood sugar without gym intimidation. Track fasting insulin, not just glucose, aiming below 10 μU/mL. For busy schedules, prep one "CFP sheet pan meal" weekly: combine non-starchy vegetables, healthy fats, and lean protein roasted together. These small wins rebuild trust after past diet failures.

The Critical Role of Cortisol and Stress Hormones

Cortisol, your primary stress hormone, directly sabotages natural weight loss. Elevated levels from chronic stress promote abdominal fat storage, increase cravings, and impair thyroid function—worsening midlife hormonal shifts. Studies show cortisol spikes can raise blood pressure and blood sugar, complicating your diabetes management. In the CFP framework, we target this with "stress snacks": 5-minute breathwork (4-7-8 pattern) before meals to lower cortisol by up to 23%. Prioritize 7-8 hours sleep; even one poor night raises next-day cortisol 37%. If embarrassment keeps you from asking for help, remember community support reduces perceived stress dramatically.

Overcoming Overwhelm: Your Personalized CFP Roadmap

Ignore conflicting nutrition advice by following this rule: eat real food within a 10-12 hour window. Supplement wisely with magnesium glycinate (300mg nightly) to calm stress hormones and support joints. Reassess every 4 weeks using waist circumference (<35 inches for women, <40 for men) rather than scale weight. If progress stalls, investigate hidden inflammation from poor sleep or emotional eating. You've already proven you can succeed—now layer these habits to make results permanent. Thousands in our community have maintained 10-20kg losses naturally after medications by focusing on cortisol control first. Start today with one walk and one breathing session; momentum builds from there.

💬 What the Community Says

Users who lost 10-15kg on Mounjaro often share excitement turning to anxiety about regain once stopping the medication. Many in the 45-54 age group report cortisol-related plateaus, with stress from work and family life making natural maintenance feel impossible. A common theme is relief finding low-impact walking plans that don't aggravate joint pain, though opinions split on strict carb limits versus moderate approaches. Beginners frequently mention embarrassment seeking help, leading to solo experiments that sometimes backfire. Most appreciate simple meal prep ideas that fit real schedules and budgets, especially those managing blood pressure and diabetes. A vocal minority warns against ignoring sleep and stress, citing personal rebounds when life got chaotic. Overall sentiment leans hopeful but cautious, with repeated calls for realistic, non-gym strategies that address hormonal realities.
Cite this answer
Clark, R. (2026). Where to go from here? I lost 13kg on mounjaro, but I am doing the rest naturall. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/where-to-go-from-here-i-lost-13kg-on-mounjaro-but-i-am-doing-the-rest-naturally-advice-and-the-role-of-cortisol-and-stress-hormones
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

📖 The 30-Week Tirzepatide Reset — Get the Book →
Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ What is the connection between Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better and its effect on metabolism and insulin levels? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation: best practices and common mistakes to avoid? 📖 Bio-Individuality — The understanding that every patient’s metabolic journey is unique, requiring a personalized approach to dosing and diet… ▸ What do you eat grain/carb wise, and why — how a functional medicine approach differs and how it connects to gut health and inflammation? ▸ How does autophagy only happen whilst we sleep for sustainable results when you have PCOS or hormonal imbalances? ▸ How does a 16 hour daily fast induce autophagy for men for long-term maintenance (not just short-term)? ▸ Omnipod. Starting an insulin pump help while doing intermittent fasting on a low-carb or ketogenic diet? ▸ Does okra water actually help gut issues: what to track and how to measure progress — what certified coaches recommend? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ What's the dumbest thing you and/or your siblings did when you were left home alone for those with hypothyroidism or Hashimoto's when you have PCOS or hormonal imbalances? ▸ I sometimes feel like people only talk about the obvious symptoms like irregular periods or weight gain, but the fatigue can be just as overwhelming. Has anyone else felt completely drained even: how to talk to your doctor about this: best practices and common mistakes to avoid? 📖 One Box Protocol — A revolutionary approach where we stretch one 60 mg box of tirzepatide across three metabolic phases, prioritizing long-… ▸ Why cant i lose weight and am gaining weight when you have PCOS or hormonal imbalances while doing intermittent fasting? ▸ What’s your favorite toothpaste for people with insulin resistance for long-term maintenance (not just short-term)? ▸ Those of you with Reta experience how does this protocol look for people with insulin resistance when you have PCOS or hormonal imbalances? ▸ Beef/Beef organs protein powder: what to track and how to measure progress if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What are the wegovy doses in order on a low-carb or ketogenic diet if you're on a GLP-1 like semaglutide or tirzepatide? ▸ My weight loss progress so far as a 23 year male who stared eating less unhealthy and does little to moderate exercise. Am I doing well — evidence-based answer for CFP patients for people with insulin resistance? 📖 Hashimoto’s Success — Achieving weight loss and reduced inflammation in thyroid patients by removing dietary triggers like lectins and modern … 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ What is the connection between Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better and how it connects to gut health and inflammation? ▸ How are people using 10mg reta vials at low doses during the weight loss plateau phase — what the research actually says? ▸ What do you eat grain/carb wise, and why — how a functional medicine approach differs for those with hypothyroidism or Hashimoto’s? 📖 Anti-Inflammatory Protocol — A way of eating that prioritizes whole foods and eliminates triggers to quiet the internal 'fire' that prevents fat cell… ▸ Weight loss without GLP-1 — what does the research actually say while doing intermittent fasting? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation and how it connects to gut health and inflammation? ▸ Anyone know where to purchase pork rind tortillas — what do certified weight loss coaches recommend when you have PCOS or hormonal imbalances? ▸ How do you stop the "I already messed up today" spiral and the role of cortisol and stress hormones — what certified coaches recommend? ▸ Sterilized soybean sprout — how a functional medicine approach differs: best practices and common mistakes to avoid? 📖 Modern Wheat Dangers — The hidden threat in hybridized grains that causes gut inflammation and spikes blood sugar more aggressively than pure t… ▸ How many were first diagnosed with OCD for long-term maintenance (not just short-term) if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Is anyone else worried about judgment from others for those with hypothyroidism or Hashimoto's if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Low TSH, Low T4, and Low T3 simultaneously on Levothyroxine — anyone experienced this and the role of cortisol and stress hormones — what certified coaches recommend? ▸ Will eating meintenance calories make me lose weight for those with hypothyroidism or Hashimoto's when you have PCOS or hormonal imbalances? ▸ Testosterone how long does it take to work while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? 📖 30-Week Tirzepatide Reset — Our signature protocol using a single 60 mg box of medication cycled over 30 weeks to achieve lasting metabolic transfor… ▸ Has anyone here made their own custom CGM patches with a Cricut for those with hypothyroidism or Hashimoto's during the weight loss plateau phase? ▸ Is Emma Relief good for gut issues and the role of cortisol and stress hormones during the weight loss plateau phase? ▸ Thyroid tests all in range— but high calcium — how a functional medicine approach differs during the weight loss plateau phase? ▸ Can autophagy regenerate muscle during physically active prolonged fast and how it connects to gut health and inflammation and its effect on metabolism and insulin levels? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Crust check 🔥 ribeye done right for long-term maintenance (not just short-term)? ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid specifically for women over 40? 📖 The Clark Protocol — Our evidence-based framework that combines clinical nurse practitioner expertise with personal experience to solve the o… ▸ I wanted to ask what is the science behind not allowing any fat during the fat burning phase like how critical is it if I ever had a tiny bit of half-and-half or a tiny bit of olive oil? Is it really do something to the body. ▸ The cost of meat is soaring, especially beef. What are y’all doing to stay on budget on a low-carb or ketogenic diet? ▸ What to do if you have to eat late dinners?? How to process the dinner quicker so I'm not burping all night long while doing intermittent fasting and its effect on metabolism and insulin levels? ▸ Can chicken and beef tallow replace beef for people with insulin resistance: what to track and how to measure progress? ▸ Have you seen this? Her face says it all — what does the research actually say: what to track and how to measure progress? ▸ Exercise — when and what kind while fasting, and does it enhance autophagy — how a functional medicine approach differs specifically for women over 40? ▸ Got diagnosed today, where do i go from here — what do certified weight loss coaches recommend — what certified coaches recommend? 📖 Adipose Tissue Signaling — The way fat cells communicate with the brain; our goal is to fix these signals so the body stops defending an unnaturall… ▸ When the fatigue is real: how to talk to your doctor about this for people with insulin resistance? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ My weight loss progress so far as a 23 year male who stared eating less unhealthy and does little to moderate exercise. Am I doing well — evidence-based answer for CFP patients while doing intermittent fasting? ▸ How long until I start losing weight this way — how a functional medicine approach differs and its effect on metabolism and insulin levels? ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say for those with hypothyroidism or Hashimoto’s? 📖 Leptin Sensitivity — Restoring your brain's ability to hear the 'I am full' signal, which is often muted by high-sugar diets and systemic inf… ▸ Should I be worried yet, been sitting for 5 days no movement while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Is it okay for teenagers to do longterm lowcarb/keto — evidence-based answer for CFP patients for those with hypothyroidism or Hashimoto’s? ▸ Fitter or kidding myself: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ How effective is autophagy really helping me lose fat — what certified coaches recommend?