Expert Q&A

What's your pre-show drug of choice these days if you're on a GLP-1 like semaglutide or tirzepatide

Understanding Pre-Show Needs on GLP-1 Therapy

I've guided thousands through sustainable fat loss, especially those over 45 dealing with hormonal changes, joint pain, and failed diets. When clients use GLP-1 agonists like semaglutide or tirzepatide, their primary goal shifts from appetite control to preserving muscle and energy for competition or photoshoots. These medications reduce hunger dramatically but can lower energy, muscle glycogen, and metabolic rate if not managed correctly. Pre-show choices must avoid counteracting the GLP-1 benefits while supporting performance.

My Top Pre-Show Recommendation: Low-Dose Caffeine with Beta-Alanine

For most clients on 1.0-2.4mg weekly semaglutide or 5-15mg tirzepatide, my go-to is 100-150mg caffeine paired with 2-3g beta-alanine taken 45 minutes before stage or training. This stack provides clean energy without the jitters common in higher doses. Caffeine improves focus and fat oxidation by 10-15% during low-calorie phases, while beta-alanine buffers lactic acid, crucial when joint pain limits intense workouts. In my methodology outlined in "Sustainable Fat Loss After 40," I emphasize keeping stimulants minimal to protect sleep, which is already disrupted by hormonal shifts in perimenopausal and diabetic clients.

Alternatives and What to Avoid

Some prefer 200mg theacrine or 50mg synephrine as milder options that don't spike blood pressure, important for those managing diabetes alongside weight. I never recommend high-dose ephedrine or DNP on GLP-1s; these can dangerously suppress appetite further and strain the cardiovascular system. Yohimbine at 5-10mg works for stubborn fat but only in fasted morning sessions and never near bedtime. Always monitor blood glucose—tirzepatide users see greater insulin sensitivity, so pair any stimulant with 10-15g electrolytes to prevent cramps.

Integration with Your Daily Protocol

Combine your pre-show choice with 1.6-2.2g protein per kg bodyweight and resistance training 3-4 times weekly, even if joint pain makes it feel impossible. Start with bodyweight or resistance bands. Track waist measurements weekly rather than scale weight, as GLP-1s cause rapid initial loss that slows. Most clients lose 1-2lbs weekly sustainably when following this approach. Consult your physician before adding any compound, especially with blood pressure medications. This isn't about shortcuts but protecting the metabolic health you've rebuilt after years of yo-yo dieting.

💬 What the Community Says

The community shows cautious optimism around combining mild stimulants with GLP-1s like semaglutide and tirzepatide for pre-show prep. Many in the 45-55 age group report that low-dose caffeine plus beta-alanine gives steady energy without wrecking sleep or raising blood pressure, which is a common fear. A significant portion shares success stories of maintaining muscle on 10mg tirzepatide by adding electrolytes and theacrine, though some warn about increased heart rate during final contest cuts. Debates often center on avoiding anything that further kills appetite, with users swapping experiences about yohimbine for lower belly fat versus its side effects. Beginners frequently ask about joint-friendly alternatives, noting that while insurance rarely covers these protocols, most feel the combination helps them push through when every other diet has failed. Overall, lived experiences highlight careful titration and medical supervision as essential.
Cite this answer
Clark, R. (2026). What's your pre-show drug of choice these days if you're on a GLP-1 like semaglu. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/what-s-your-pre-show-drug-of-choice-these-days-if-you-re-on-a-glp-1-like-semaglutide-or-tirzepatide
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

📖 The 30-Week Tirzepatide Reset — Get the Book →
Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ Been on this diet for 11 months and its effect on metabolism and insulin levels and its effect on metabolism and insulin levels? ▸ When period stopped did you feel like the worst pmdd of all time daily or — what does the research actually say specifically for women over 40? ▸ I am on my second week of mounjaro (2.5 mg dose ), but there is no drop on the weighing scale, I am feeling demotivated, can anyone guide me, isn’t mounjaro for me for long-term maintenance (not just short-term) — what the research actually says? ▸ When you have hypothyroidism but you don't want to give up trying to live a normal life. 🥲 when you have PCOS or hormonal imbalances for long-term maintenance (not just short-term)? ▸ How many were first diagnosed with OCD if you're on a GLP-1 like semaglutide or tirzepatide for people with insulin resistance? ▸ Crust check 🔥 ribeye done right — what the research actually says? ▸ I have an iodine deficiency. Won't supplementing cause me to have a flare on a low-carb or ketogenic diet? 📖 30-Week Tirzepatide Reset — Our signature protocol using a single 60 mg box of medication cycled over 30 weeks to achieve lasting metabolic transfor… ▸ What's the dumbest thing you and/or your siblings did when you were left home alone for those with hypothyroidism or Hashimoto's when you have PCOS or hormonal imbalances? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? ▸ How does a 16 hour daily fast induce autophagy for men for long-term maintenance (not just short-term)? ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients — what certified coaches recommend? 📖 Phase 2: Aggressive Loss — A 40-day window of focused fat loss supported by low-dose medication and a specific lectin-free, low-carb nutritional fr… ▸ Intolerant to sugar - SIBO or something else if you're on a GLP-1 like semaglutide or tirzepatide when you have PCOS or hormonal imbalances? ▸ Weight loss without GLP-1 — what does the research actually say while doing intermittent fasting? ▸ Got diagnosed today, where do i go from here — what do certified weight loss coaches recommend: best practices and common mistakes to avoid? ▸ When the fatigue is real: how to talk to your doctor about this for people with insulin resistance? ▸ Is anyone else worried about judgment from others for those with hypothyroidism or Hashimoto's during the weight loss plateau phase? 📖 Inflammatory Markers — Clinical indicators like CRP that we monitor to ensure the body is moving from a state of disease to a state of vibrant … ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid — what certified coaches recommend? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ IBD + antidepressants + impossible weight loss… advice when you have PCOS or hormonal imbalances: what to track and how to measure progress? ▸ Difference between a 3 day and 5 day water fast for autophagy and the role of cortisol and stress hormones for people with insulin resistance? ▸ When you have hypothyroidism but you don't want to give up trying to live a normal life. 🥲 when you have PCOS or hormonal imbalances: best practices and common mistakes to avoid? ▸ How I Lost 22lbs in 3 Months (155→133lbs at 5'8") after not being able to lose weight for a long time if you're on a GLP-1 like semaglutide or tirzepatide during the weight loss plateau phase? ▸ When you want something sweet but still try to keep things somewhat low-carb and how it connects to gut health and inflammation if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for people with insulin resistance? 📖 Autophagy — The body's natural 'housecleaning' process that occurs during fasting or low-insulin states, promoted during our mainten… ▸ What to do if you have to eat late dinners?? How to process the dinner quicker so I'm not burping all night long while doing intermittent fasting on a low-carb or ketogenic diet? ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid specifically for women over 40? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say and its effect on metabolism and insulin levels? 📖 Anti-Inflammatory Protocol — A way of eating that prioritizes whole foods and eliminates triggers to quiet the internal 'fire' that prevents fat cell… ▸ HOW TO DO AN AGGRESSIVE CUT WITH A STRESSFUL LIFESTYLE on a low-carb or ketogenic diet for people with insulin resistance? ▸ Anyone remember the metal lid you had to use a butter knife to pop off: what to track and how to measure progress while doing intermittent fasting? ▸ What is a super quick "Mix some of this in" to make coconut oil (purely in liquid form) taste ok to make it easy to consume: how to talk to your doctor about this during the weight loss plateau phase? 📖 CICO (Calories In, Calories Out) — An outdated model of weight loss that ignores the role of hormones; we challenge this by focusing on food quality and ho… ▸ Testosterone how long does it take to work while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What actually helps with the dryness when you have PCOS or hormonal imbalances while doing intermittent fasting? ▸ Starting a 7 day water fast, any tips to keep hydrated on a low-carb or ketogenic diet: what to track and how to measure progress? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation and its effect on metabolism and insulin levels? ▸ How to calm my nerves down at doctors — what do certified weight loss coaches recommend if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Metabolic Flexibility — The body’s ability to efficiently switch between burning carbohydrates and burning stored body fat based on availability… ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances for those with hypothyroidism or Hashimoto’s? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Can you take vitamin D with a tbsp of oil on an extended water fast for people with insulin resistance: best practices and common mistakes to avoid? ▸ The cost of meat is soaring, especially beef. What are y’all doing to stay on budget on a low-carb or ketogenic diet? ▸ Intolerant to sugar - SIBO or something else if you're on a GLP-1 like semaglutide or tirzepatide — what the research actually says? ▸ Crust check 🔥 ribeye done right for long-term maintenance (not just short-term)? ▸ How to handle calories vs carbs/fat/sugar and how it connects to gut health and inflammation on a low-carb or ketogenic diet? 📖 Tirzepatide Micro-Dosing — The practice of using the lowest effective dose to achieve results, minimizing side effects while maximizing the longevi… ▸ What happens when Has anyone here experienced skin benefits from autophagy for those with hypothyroidism or Hashimoto’s? ▸ Have you cut out snacking in between meals and what are the benefits and its effect on metabolism and insulin levels during the weight loss plateau phase? ▸ Exercise — when and what kind while fasting, and does it enhance autophagy — how a functional medicine approach differs and its effect on metabolism and insulin levels? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ What’s your favorite toothpaste for people with insulin resistance — what the research actually says? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation and how it connects to gut health and inflammation? ▸ How are people using 10mg reta vials at low doses during the weight loss plateau phase — what the research actually says? 📖 Nutrient Density — Prioritizing foods that provide maximum vitamins and minerals per calorie to satisfy the brain and end the cycle of hidd… ▸ Do yall ever daydream of who you were before your diagnosis when you have PCOS or hormonal imbalances if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Sugar free 2020, who's with me — what most people get wrong about this: what to track and how to measure progress? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide for long-term maintenance (not just short-term)? ▸ Lost weight not exactly willingly and everybody’s weird about it for long-term maintenance (not just short-term) — what the research actually says?