Expert Q&A

How long have we known that diabetes can be cured by not eating any carbs? Can you guess and the role of cortisol and stress hormones

The Historical Timeline of Low-Carb Diabetes Management

Physicians have recognized the benefits of carbohydrate restriction for diabetes since the late 18th century. In 1797, Dr. John Rollo successfully treated a patient with a diet high in animal fats and proteins while eliminating sugars and starches. By the early 1900s, Frederick Madison Allen's starvation-style low-carb protocols achieved remission in many cases before insulin's discovery in 1921. In my book The Metabolic Reset, I detail how these early observations laid the groundwork for what we now understand as type 2 diabetes reversal through dietary means.

The Modern Understanding and Clinical Evidence

Since the 1970s, researchers like Dr. Robert Atkins and later Dr. Richard Bernstein demonstrated that eliminating carbs stabilizes blood glucose without medication for many patients. Recent studies, including the 2019 Virta Health trial, showed 60% of participants achieved diabetes remission after one year on a ketogenic protocol under 50 grams of carbs daily. For middle-aged adults like you managing both diabetes and blood pressure, this approach addresses hormonal changes that make weight loss difficult after 45.

The Critical Role of Cortisol and Stress Hormones

Cortisol, our primary stress hormone, directly raises blood sugar by triggering gluconeogenesis in the liver. Chronic elevation from work pressure, poor sleep, or emotional strain keeps insulin resistance high even on low-carb diets. In The Metabolic Reset, I explain the cortisol-insulin feedback loop: elevated cortisol promotes abdominal fat storage, which then secretes inflammatory cytokines worsening blood sugar control. Stress hormones like adrenaline further spike glucose through glycogen breakdown. Beginners often overlook this; without addressing stress hormones, even perfect carb restriction yields slower results.

Practical Beginner Strategies for Sustainable Success

Start with a simple 20-50 gram carb limit using whole foods—no complex meal plans needed. Pair this with 10-minute daily walks to reduce joint pain and lower cortisol naturally. Track fasting blood glucose and ketones to confirm your body shifts from sugar-burning to fat-burning within 7-14 days. For those embarrassed about obesity or frustrated by past diet failures, this isn't another restrictive fad; it's a metabolic reset that works with your hormones. Many in their 50s see blood pressure improvements within weeks, often reducing medications under physician guidance. Consistency beats perfection—focus on progress while managing real-life stress through short breathing exercises.

💬 What the Community Says

In online forums and support groups, middle-aged adults express excitement about low-carb diabetes reversal but remain skeptical due to decades of "eat less, move more" advice. Many share stories of A1C dropping from 8.5 to 5.8 within months after cutting carbs, yet a vocal minority reports stalled progress blaming hidden stress and cortisol issues. Beginners frequently discuss joint pain barriers and time constraints, with several noting insurance limitations pushed them toward self-guided approaches. Lived experiences highlight hormonal shifts in perimenopause and andropause making traditional diets ineffective. Debates often center on sustainability versus keto extremes, with most agreeing stress management is the missing piece. Overall sentiment mixes hope from success stories with caution from repeated past failures, creating active discussions around practical, low-effort routines that fit busy lives.
Clark, R. (2026). How long have we known that diabetes can be cured by not eating any carbs? Can y. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/how-long-have-we-known-that-diabetes-can-be-cured-by-not-eating-any-carbs-can-you-guess-and-the-role-of-cortisol-and-stress-hormones
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
How I cured my bad breath. Especially helpful for people with sinus issues: what to track and how to measure progress: what to track and how to measure progress? Anybody else wake up after 5-6 hours because their lower back starts hurting if you're on a GLP-1 like semaglutide or tirzepatide and how it connects to gut health and inflammation? Do you know any good empirical studies on LCHF and its effect on metabolism and insulin levels when you have PCOS or hormonal imbalances? 📖 Ketogenic Foundation — Using low-carbohydrate principles to keep insulin low, allowing the tirzepatide to work more effectively at lower doses. Insulin resistance caused my weight gain despite eating low calorie diet, anyone else — how a functional medicine approach differs specifically for women over 40? Anybody else wake up after 5-6 hours because their lower back starts hurting — what does the research actually say for long-term maintenance (not just short-term)? Gaining tons of weight but normal levels — what does the research actually say for long-term maintenance (not just short-term)? How the heck do people with health anxiety handle anxiety med side effects: what to track and how to measure progress — what the research actually says? Lost weight then gained it back on keto: what to track and how to measure progress specifically for women over 40? How Much Does 200g Apple Raise Blood Sugar when you have PCOS or hormonal imbalances and its effect on metabolism and insulin levels? Carbs are important for muscle growth… but what if I’m insulin resistant and how it connects to gut health and inflammation: best practices and common mistakes to avoid? 📖 CICO (Calories In, Calories Out) — An outdated model of weight loss that ignores the role of hormones; we challenge this by focusing on food quality and ho… 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 Any Links Between Autophagy & Eye Disease Reversing when you have PCOS or hormonal imbalances for people with insulin resistance? What's a physical thing you can do TODAY that you couldn't do at 40 for those with hypothyroidism or Hashimoto's on a low-carb or ketogenic diet? How long was your withdrawal when you went sugarfree if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? When fed ex secures the goods when you have PCOS or hormonal imbalances while doing intermittent fasting? How I cured my bad breath. Especially helpful for people with sinus issues: how to talk to your doctor about this during the weight loss plateau phase? What a month of paleo has done for me while doing intermittent fasting and its effect on metabolism and insulin levels? One Medical for Lilly Direct on a low-carb or ketogenic diet during the weight loss plateau phase? 📖 Metabolic Reset — The process of retraining your body to utilize stored fat for fuel and regulating hunger hormones so you can maintain yo… Tracking carbs in Resistant Starch: Do you count them differently after 24h in the fridge — what does the research actually say and its effect on metabolism and insulin levels? After losing weight, does it feel like you could do anything — evidence-based answer for CFP patients when you have PCOS or hormonal imbalances? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 When you want something sweet but still try to keep things somewhat low-carb for long-term maintenance (not just short-term) for those with hypothyroidism or Hashimoto’s? Been going out with this girl and I think it’s destroyed my microbiome for people with insulin resistance while doing intermittent fasting? Am I doing this correctly for those with hypothyroidism or Hashimoto's — what certified coaches recommend? Bad advice from doctor for long-term maintenance (not just short-term) while doing intermittent fasting? 📖 Strategic Fat Loading — A critical 48-hour phase at the start of the reset where we prime the body with healthy fats to trigger the transition f… What's your pre-show drug of choice these days and its effect on metabolism and insulin levels and its effect on metabolism and insulin levels? When Someone Paid by Credit Card, We Had to Drag Out This — what most people get wrong about this and how it connects to gut health and inflammation? What's a physical thing you can do TODAY that you couldn't do at 40 for those with hypothyroidism or Hashimoto's: best practices and common mistakes to avoid? When you get your microdose calculations wrong for the Monday morning meeting for people with insulin resistance if you're on a GLP-1 like semaglutide or tirzepatide? How did I not get a heads up? I now make it my goal to help, support and inform others heading towards menooause and its effect on metabolism and insulin levels — what certified coaches recommend? Can sugar free candy make a difference and how it connects to gut health and inflammation: what to track and how to measure progress? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 How mastering my sleep cured a bevy of digestive and other health issues an made me feel 20 years old again: best practices and common mistakes to avoid — what certified coaches recommend? 📖 Tirzepatide Micro-Dosing — The practice of using the lowest effective dose to achieve results, minimizing side effects while maximizing the longevi… Stacking NMN with TMG, what's your morning fasted protocol look like for people with insulin resistance while doing intermittent fasting? Starting my second extended fast tomorrow. Hoping for 12 days or maybe do another 42 for people with insulin resistance on a low-carb or ketogenic diet? What made you start carnivore and how it connects to gut health and inflammation? Can Maintenance Phase do an episode about pregnancy weight gain — what do certified weight loss coaches recommend if you're on a GLP-1 like semaglutide or tirzepatide? Does anyone else remember the darkest time of our Generation — evidence-based answer for CFP patients — what certified coaches recommend? 📖 Gut-Brain Axis — The complex communication network between your digestive system and your brain that controls satiety, mood, and metaboli… Here's the things I wish I'd known back then... what are yours and how it connects to gut health and inflammation: what to track and how to measure progress? Any Links Between Autophagy & Eye Disease Reversing when you have PCOS or hormonal imbalances: what to track and how to measure progress? What was your wake up call that you needed to lose the weight or you might die — what does the research actually say — what certified coaches recommend? How to get better cholesterol test scores during the weight loss plateau phase if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 When you want something sweet but still try to keep things somewhat low-carb for long-term maintenance (not just short-term) if you're on a GLP-1 like semaglutide or tirzepatide? How it's going for me and how BMI has betrayed the tall girlies: what to track and how to measure progress while doing intermittent fasting? Is the carnivore diet the best WOE to lose weight while doing intermittent fasting: best practices and common mistakes to avoid? 📖 Metabolic Stall — A plateau in weight loss often caused by hidden inflammation or hormonal adaptation, which we break using our specific 7… Being underweight, panic and anxiety. Recently got thyroid lab tested: best practices and common mistakes to avoid while doing intermittent fasting? Any of you low carb, low to no fruits people go camping? Even if not, what are you eating and how it connects to gut health and inflammation while doing intermittent fasting? Has anyone with loose skin tried water fasting for long periods of time? and hie did it effect the loose skin and how it connects to gut health and inflammation if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Nutrient Density — Prioritizing foods that provide maximum vitamins and minerals per calorie to satisfy the brain and end the cycle of hidd… Depressive symptoms from non-stick air fryer — what do certified weight loss coaches recommend if you're on a GLP-1 like semaglutide or tirzepatide? Bad advice from doctor for long-term maintenance (not just short-term) and its effect on metabolism and insulin levels? Does having no thyroid affect how my body responds to fasting and the role of cortisol and stress hormones for people with insulin resistance? Does anyone else love masks mandated so I can hide my facial hair — what most people get wrong about this for long-term maintenance (not just short-term)? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 Frustrated with lack of progress. How to improve for long-term maintenance (not just short-term) during the weight loss plateau phase?