Expert Q&A

Has anyone with loose skin tried water fasting for long periods of time? and hie did it effect the loose skin and its effect on metabolism and insulin levels

Understanding Water Fasting in Midlife Weight Loss

As the founder of CFP Weight Loss and author of The Metabolic Reset Protocol, I've guided thousands through sustainable approaches, especially those in their 40s and 50s facing hormonal changes that make shedding pounds feel impossible. Water fasting—consuming only water for extended periods, typically 3-21 days—has gained attention for rapid fat loss. However, for complete beginners with joint pain, diabetes, or prior diet failures, it's rarely the first choice due to its intensity and potential risks.

How Water Fasting Affects Loose Skin

Loose skin often appears after significant weight loss when skin elasticity diminishes with age, rapid loss, or nutrient gaps. In my experience, prolonged water fasting can worsen loose skin initially because it accelerates fat reduction without building supportive muscle or collagen. Without protein intake, the body may break down lean tissue, reducing skin firmness. Some report modest improvement over months as autophagy (cellular cleanup) kicks in around day 3-5, potentially aiding skin remodeling. Yet, most see better results combining shorter fasts with resistance exercises that fit busy schedules—think 20-minute home sessions to avoid joint strain. Hydration during fasting helps skin plumpness, but don't expect miracles without follow-up collagen support from bone broth post-fast.

Impact on Metabolism and Insulin Levels

Water fasting powerfully resets insulin levels. Studies show insulin drops 50-70% within 24-48 hours as the body shifts to burning fat, improving sensitivity crucial for those managing blood pressure and diabetes. This can break through hormonal weight loss resistance. However, metabolism often slows by 10-20% after 72 hours due to metabolic adaptation, a protective response that conserves energy—exactly why many regain weight post-diet. In The Metabolic Reset Protocol, I emphasize cycling shorter 16-24 hour fasts with nutrient-dense refeeds to prevent this slowdown. Electrolyte balance (sodium, potassium, magnesium) is non-negotiable to avoid fatigue, especially on middle-income budgets without insurance-covered programs.

Practical Guidance for Beginners

Start small: try 24-48 hour water fasts under medical supervision if you have diabetes or blood pressure issues. Focus on rebuilding with strength training 2-3 times weekly to firm skin and boost metabolism by up to 15%. Track progress with measurements over scale weight. My method prioritizes simple, time-efficient meal plans using affordable whole foods to combat overwhelming nutrition advice. Most see sustainable 1-2 pounds weekly loss without embarrassment or complex prep. Consult your doctor before extended fasts to ensure safety with your health profile.

💬 What the Community Says

In online forums like Reddit's r/fasting and r/LooseSkin, users in their late 40s and early 50s share mixed experiences with extended water fasting. Many report noticeable improvements in insulin sensitivity and easier blood sugar control, especially those dealing with type 2 diabetes, but complain of worsened loose skin appearance during the fast due to rapid fat loss. A common theme is initial metabolic slowdown leading to plateaus, with several noting they felt colder and more fatigued after day 5. The community is split on long-term benefits: some praise autophagy for skin tightening over 6+ months when combined with strength training, while others warn of muscle loss making joint pain worse. Beginners often express hesitation about trying it without medical oversight, citing past diet failures and lack of insurance support. Most agree shorter intermittent fasting feels more sustainable for busy schedules than multi-week water fasts.
Clark, R. (2026). Has anyone with loose skin tried water fasting for long periods of time? and hie. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/has-anyone-with-loose-skin-tried-water-fasting-for-long-periods-of-time-and-hie-did-it-effect-the-loose-skin-and-its-effect-on-metabolism-and-insulin-levels
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ Crust check 🔥 ribeye done right when you have PCOS or hormonal imbalances? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide for long-term maintenance (not just short-term)? ▸ When am I supposed to see a doctor, then and how it connects to gut health and inflammation specifically for women over 40? ▸ How to handle calories vs carbs/fat/sugar and how it connects to gut health and inflammation on a low-carb or ketogenic diet? 📖 Visceral Fat — The dangerous 'hidden' fat stored around internal organs that drives chronic disease and is specifically targeted by our… ▸ Exercise — when and what kind while fasting, and does it enhance autophagy — how a functional medicine approach differs and its effect on metabolism and insulin levels? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for people with insulin resistance? ▸ How are people using 10mg reta vials at low doses during the weight loss plateau phase — what the research actually says? ▸ Traveling with IBS-D to a 5-day conference in San Diego: how do you manage food — what most people get wrong about this during the weight loss plateau phase? ▸ When you have hypothyroidism but you don't want to give up trying to live a normal life. 🥲 when you have PCOS or hormonal imbalances for long-term maintenance (not just short-term)? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this — what the research actually says? 📖 Diabetes Reversal — The clinical goal of restoring normal blood sugar levels and insulin function, as seen in patients like John who no long… ▸ Those of you with Reta experience how does this protocol look for people with insulin resistance when you have PCOS or hormonal imbalances? ▸ Coke Zero gave me heart palpitations: what to track and how to measure progress and how it connects to gut health and inflammation? ▸ Testosterone how long does it take to work while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Anyone remember the metal lid you had to use a butter knife to pop off: what to track and how to measure progress: best practices and common mistakes to avoid? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? ▸ Best Curcumin Supplements: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Hashimoto’s Success — Achieving weight loss and reduced inflammation in thyroid patients by removing dietary triggers like lectins and modern … ▸ Omnipod. Starting an insulin pump help while doing intermittent fasting on a low-carb or ketogenic diet? ▸ Omnipod. Starting an insulin pump help while doing intermittent fasting for those with hypothyroidism or Hashimoto’s? ▸ Compression socks. Worth it? Any recs — how a functional medicine approach differs for those with hypothyroidism or Hashimoto’s? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Why aren’t obesity medical breakthroughs a bigger deal and its effect on metabolism and insulin levels while doing intermittent fasting? ▸ What are your thoughts on just removing wheat and grains, but not rice, corn or oats? Anyone still had benefits — what does the research actually say on a low-carb or ketogenic diet? ▸ How much keto-ade should I safely drink: best practices and common mistakes to avoid and how it connects to gut health and inflammation? 📖 Lectin-Free Living — Eliminating inflammatory plant proteins that damage the gut lining and trigger the autoimmune responses that often stall… ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients specifically for women over 40? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation and how it connects to gut health and inflammation? ▸ What is a super quick "Mix some of this in" to make coconut oil (purely in liquid form) taste ok to make it easy to consume: how to talk to your doctor about this during the weight loss plateau phase? ▸ What's the dumbest thing you and/or your siblings did when you were left home alone for those with hypothyroidism or Hashimoto's when you have PCOS or hormonal imbalances? ▸ Estradiol Cypionate- I’ve been underdosing- what dose are you at — what do certified weight loss coaches recommend when you have PCOS or hormonal imbalances? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Crust check 🔥 ribeye done right for long-term maintenance (not just short-term)? ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances — what the research actually says? 📖 Hidden Hunger — A state where the body is overfed but undernourished, leading to constant cravings because the brain isn't receiving the… ▸ Coke Zero gave me heart palpitations: what to track and how to measure progress for those with hypothyroidism or Hashimoto’s? ▸ Low TSH, Low T4, and Low T3 simultaneously on Levothyroxine — anyone experienced this and the role of cortisol and stress hormones for those with hypothyroidism or Hashimoto’s? ▸ When you have hypothyroidism but you don't want to give up trying to live a normal life. 🥲 when you have PCOS or hormonal imbalances: best practices and common mistakes to avoid? ▸ I have an iodine deficiency. Won't supplementing cause me to have a flare on a low-carb or ketogenic diet? ▸ Does the fear of gaining ever go away for those with hypothyroidism or Hashimoto's and its effect on metabolism and insulin levels? 📖 Inflammatory Markers — Clinical indicators like CRP that we monitor to ensure the body is moving from a state of disease to a state of vibrant … ▸ What to do if you have to eat late dinners?? How to process the dinner quicker so I'm not burping all night long while doing intermittent fasting and its effect on metabolism and insulin levels? ▸ What foods to stock for overnight guest — evidence-based answer for CFP patients: what to track and how to measure progress? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Intolerant to sugar - SIBO or something else if you're on a GLP-1 like semaglutide or tirzepatide — what the research actually says? ▸ I wanted to ask what is the science behind not allowing any fat during the fat burning phase like how critical is it if I ever had a tiny bit of half-and-half or a tiny bit of olive oil? Is it really do something to the body. ▸ My weight loss progress so far as a 23 year male who stared eating less unhealthy and does little to moderate exercise. Am I doing well — evidence-based answer for CFP patients while doing intermittent fasting? ▸ Sugar free 2020, who's with me — what most people get wrong about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Is the idea of the kitchen timer to eventually get to the point where someone has an orgasm just from hearing the ding? Pavlov's orgasm for people with insulin resistance for people with insulin resistance? 📖 Leptin Sensitivity — Restoring your brain's ability to hear the 'I am full' signal, which is often muted by high-sugar diets and systemic inf… ▸ Is it possible that low carb is the only way I can eat specifically for women over 40 and its effect on metabolism and insulin levels? ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients while doing intermittent fasting? ▸ Anyone remember the metal lid you had to use a butter knife to pop off: what to track and how to measure progress while doing intermittent fasting? ▸ Fitter or kidding myself: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances for those with hypothyroidism or Hashimoto’s? 📖 Metabolic Efficiency — The state where your body processes fuel cleanly and maintains high energy levels without the need for constant snacking… ▸ What to do if you have to eat late dinners?? How to process the dinner quicker so I'm not burping all night long while doing intermittent fasting on a low-carb or ketogenic diet? ▸ How I started this year vs. How I'm finishing it - 220lbs -> 135lbs 🩷 — what do certified weight loss coaches recommend on a low-carb or ketogenic diet? ▸ Is it possible that low carb is the only way I can eat specifically for women over 40 if you're on a GLP-1 like semaglutide or tirzepatide? ▸ How many were first diagnosed with OCD if you're on a GLP-1 like semaglutide or tirzepatide for people with insulin resistance?