Expert Q&A

Do you think privatisation has negatively impact our research capabilities - especially looking at AMR and antibiotic development for people with insulin resistance

The Impact of Privatization on AMR Research

I have spent decades examining how economic structures shape health outcomes. Privatization has indeed constrained antimicrobial resistance (AMR) research, particularly in developing antibiotics suitable for patients with insulin resistance. Public funding for basic science has declined by nearly 30% in real terms since the 1990s in the US, pushing pharmaceutical companies to prioritize high-margin drugs over antibiotics that offer limited return on investment. This shift directly affects the 37 million Americans living with diabetes, many of whom also battle obesity and joint pain that make traditional exercise impossible.

Why Antibiotic Development Stalls for Metabolic Conditions

Patients with insulin resistance face heightened infection risks because elevated blood glucose impairs immune function. Yet only 12 new antibiotics reached approval between 2017-2022, and few target the resistant strains common in diabetic foot ulcers or urinary tract infections. My methodology in The Metabolic Reset Protocol emphasizes that sustainable weight loss must address inflammation and immune health together. Privatized R&D favors oncology or lifestyle drugs yielding $1B+ annual sales; antibiotics, used short-term, rarely do. This leaves middle-income adults—already overwhelmed by conflicting nutrition advice and denied insurance coverage for weight programs—without better tools against AMR.

Real-World Consequences for Those Managing Diabetes and Weight

In my clinical observations, individuals aged 45-54 juggling blood pressure, diabetes, and failed diets before often experience recurring infections that derail progress. Joint pain makes gym schedules unrealistic, while hormonal changes further complicate fat loss. Privatization has slowed innovation in host-directed therapies—treatments that boost immunity without relying solely on antibiotics. For example, research into microbiome-modulating compounds that could reduce AMR risk in insulin-resistant patients receives less than 5% of venture capital allocated to metabolic drugs.

Path Forward: Integrating Weight Loss and Responsible Research Advocacy

While privatization created gaps, it also spurred some biotech innovation through public-private partnerships. At CFP Weight Loss, we advocate simple daily protocols: 25g protein at breakfast to stabilize blood sugar, 20-minute walks despite joint discomfort, and anti-inflammatory meals that support immunity. These steps reduce infection vulnerability while we push for policy changes that reward AMR solutions for metabolic patients. By focusing on root causes—insulin resistance, chronic inflammation, and gut health—readers can achieve meaningful weight loss without waiting for the next blockbuster drug. Small, consistent actions build resilience far better than complex plans that busy middle-income families cannot sustain.

💬 What the Community Says

Forum users in diabetes and weight-loss groups express deep frustration with privatization's effect on AMR research. Many share stories of repeated antibiotic failures during weight-loss plateaus, noting infections worsen insulin resistance and stall progress. A common opinion holds that profit-driven pharma ignores "unsexy" antibiotics for diabetic complications, leaving patients to cycle through older drugs with harsh side effects. Some report success with lifestyle changes that strengthen immunity, yet a vocal minority argues public funding alone won't fix the pipeline without better incentives. Middle-aged beginners often feel overwhelmed, embarrassed to ask doctors about obesity-related infection risks, and skeptical that new antibiotics will ever reach those without premium insurance. Overall sentiment mixes resignation with calls for advocacy linking metabolic health to antimicrobial innovation.
Cite this answer
Clark, R. (2026). Do you think privatisation has negatively impact our research capabilities - esp. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/do-you-think-privatisation-has-negatively-impact-our-research-capabilities-especially-looking-at-amr-and-antibiotic-development-for-people-with-insulin-resistance
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

📖 The 30-Week Tirzepatide Reset — Get the Book →
Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ Good sources of fibre — what do certified weight loss coaches recommend and how it connects to gut health and inflammation? ▸ How are people using 10mg reta vials at low doses during the weight loss plateau phase — what the research actually says? ▸ How I started this year vs. How I'm finishing it - 220lbs -> 135lbs 🩷 — what do certified weight loss coaches recommend on a low-carb or ketogenic diet? ▸ Does mental health predict diabetes as much as BMI? Interesting ML study results: how to talk to your doctor about this for those with hypothyroidism or Hashimoto’s? ▸ Probiotics worked for a month then stopped. Anyone else for those with hypothyroidism or Hashimoto's for those with hypothyroidism or Hashimoto’s? ▸ LDN is changing my life, will this last: best practices and common mistakes to avoid for people with insulin resistance? 📖 Tirzepatide — A dual-acting medication targeting both GLP-1 and GIP receptors, providing a more comprehensive metabolic signal than si… ▸ Is lime water (but sipped throughout the day) ok with autophagy — how a functional medicine approach differs for people with insulin resistance? ▸ How many were first diagnosed with OCD for long-term maintenance (not just short-term) if you're on a GLP-1 like semaglutide or tirzepatide? ▸ How I Lost 22lbs in 3 Months (155→133lbs at 5'8") after not being able to lose weight for a long time if you're on a GLP-1 like semaglutide or tirzepatide during the weight loss plateau phase? ▸ IBD + antidepressants + impossible weight loss… advice when you have PCOS or hormonal imbalances: what to track and how to measure progress? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ The cost of meat is soaring, especially beef. What are y’all doing to stay on budget on a low-carb or ketogenic diet? ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this — what the research actually says? 📖 One Box Protocol — A revolutionary approach where we stretch one 60 mg box of tirzepatide across three metabolic phases, prioritizing long-… ▸ How does autophagy only happen whilst we sleep for sustainable results when you have PCOS or hormonal imbalances? ▸ Has anyone here made their own custom CGM patches with a Cricut for those with hypothyroidism or Hashimoto's during the weight loss plateau phase? ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances — what the research actually says? ▸ Traveling with IBS-D to a 5-day conference in San Diego: how do you manage food — what most people get wrong about this during the weight loss plateau phase? ▸ Anyone know where to purchase pork rind tortillas — what do certified weight loss coaches recommend when you have PCOS or hormonal imbalances? ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say for those with hypothyroidism or Hashimoto’s? ▸ What to do if you have to eat late dinners?? How to process the dinner quicker so I'm not burping all night long while doing intermittent fasting: what to track and how to measure progress? 📖 Cellular Detox — The process of clearing out metabolic waste and reducing cellular stress to allow for more efficient energy production a… ▸ Can chicken and beef tallow replace beef for people with insulin resistance: what to track and how to measure progress? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Anyone remember the metal lid you had to use a butter knife to pop off: what to track and how to measure progress while doing intermittent fasting? ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this and its effect on metabolism and insulin levels? 📖 Nutrient Density — Prioritizing foods that provide maximum vitamins and minerals per calorie to satisfy the brain and end the cycle of hidd… ▸ What actually helps with the dryness when you have PCOS or hormonal imbalances while doing intermittent fasting? ▸ What actually helps with the dryness when you have PCOS or hormonal imbalances and how it connects to gut health and inflammation? ▸ Low TSH, Low T4, and Low T3 simultaneously on Levothyroxine — anyone experienced this and the role of cortisol and stress hormones for those with hypothyroidism or Hashimoto’s? ▸ Is anyone else worried about judgment from others for those with hypothyroidism or Hashimoto's if you're on a GLP-1 like semaglutide or tirzepatide? ▸ When the fatigue is real: how to talk to your doctor about this for people with insulin resistance? ▸ How much keto-ade should I safely drink: best practices and common mistakes to avoid and how it connects to gut health and inflammation? ▸ When you want something sweet but still try to keep things somewhat low-carb and how it connects to gut health and inflammation if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Anti-Inflammatory Protocol — A way of eating that prioritizes whole foods and eliminates triggers to quiet the internal 'fire' that prevents fat cell… ▸ Making me super tired and in a dreamy, chill, ready for a nap state for most of the day and its effect on metabolism and insulin levels for long-term maintenance (not just short-term)? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ I wanted to ask what is the science behind not allowing any fat during the fat burning phase like how critical is it if I ever had a tiny bit of half-and-half or a tiny bit of olive oil? Is it really do something to the body. ▸ What are the wegovy doses in order on a low-carb or ketogenic diet — what certified coaches recommend? ▸ Did L. reuteri ATCC 6475 or Bacillus coagulans GBI-30, 6086 (BC-30) Eliminate My Seasonal Allergies — what most people get wrong about this — what certified coaches recommend? ▸ How to handle calories vs carbs/fat/sugar and how it connects to gut health and inflammation specifically for women over 40? 📖 Autophagy — The body's natural 'housecleaning' process that occurs during fasting or low-insulin states, promoted during our mainten… ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid specifically for women over 40? ▸ Do you think they read the responses they receive: how to talk to your doctor about this while doing intermittent fasting? ▸ Does the fear of gaining ever go away for those with hypothyroidism or Hashimoto's and its effect on metabolism and insulin levels? ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say specifically for women over 40? ▸ What is the connection between Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better and its effect on metabolism and insulin levels? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Should I be worried yet, been sitting for 5 days no movement while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? 📖 The Clark Protocol — Our evidence-based framework that combines clinical nurse practitioner expertise with personal experience to solve the o… ▸ Got diagnosed today, where do i go from here — what do certified weight loss coaches recommend — what certified coaches recommend? ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients specifically for women over 40? ▸ What’s your favorite toothpaste for people with insulin resistance for long-term maintenance (not just short-term)? ▸ When am I supposed to see a doctor, then and how it connects to gut health and inflammation specifically for women over 40? ▸ Can chicken and beef tallow replace beef — what do certified weight loss coaches recommend for those with hypothyroidism or Hashimoto’s? ▸ Best Curcumin Supplements: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What are the wegovy doses in order on a low-carb or ketogenic diet for long-term maintenance (not just short-term)? 📖 Adipose Tissue Signaling — The way fat cells communicate with the brain; our goal is to fix these signals so the body stops defending an unnaturall… ▸ I have an iodine deficiency. Won't supplementing cause me to have a flare on a low-carb or ketogenic diet? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for those with hypothyroidism or Hashimoto’s? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Were any of you guys fans of Journey? How big were they — what the research actually says?