Expert Q&A

Anyone else come to the realization IR was the root cause of issues throughout your life: what to track and how to measure progress

Recognizing Insulin Resistance as the Hidden Root Cause

For many in their late 40s and early 50s, the moment of realizing insulin resistance (IR) was behind decades of stubborn weight, crashing energy, hormonal chaos, and even joint pain feels like finally solving a lifelong puzzle. In my work with thousands through the CFP Weight Loss method, I've seen this realization transform people who had "failed every diet before." IR makes fat storage easier, muscle building harder, and turns even moderate carbs into blood sugar spikes that fuel inflammation, high blood pressure, and type 2 diabetes risk. Hormonal changes in perimenopause and andropause amplify it, explaining why the same approaches that worked in your 30s suddenly stopped.

What to Track: The Essential Biomarkers and Daily Metrics

Start with fasting insulin — aim for under 10 μU/mL, ideally below 5. Most doctors only test fasting glucose (keep it 70-85 mg/dL), but that misses early IR. Calculate your HOMA-IR score using the free online calculator: (fasting glucose × fasting insulin) ÷ 405. A score above 1.9 signals resistance. Track waist circumference weekly — under 35 inches for women and 40 for men is the goal, as visceral fat directly drives IR. In the CFP method, we also monitor morning fasting blood sugar trends with a $20 glucometer and note post-meal energy crashes. Log carb intake (target 50-100g daily from vegetables and limited fruit initially) and how your joints feel after meals. Many beginners are surprised how reducing processed carbs quickly eases joint pain that made exercise feel impossible.

How to Measure Progress Without Fancy Labs

Progress isn't just the scale — that often stalls while body composition improves. Measure waist-to-height ratio monthly (aim below 0.5). Take progress photos in the same lighting every two weeks and note clothing fit. Energy levels and stable mood are key markers; many report sleeping better within 14 days. In my book The CFP Solution, I outline a simple 21-day protocol that lowers average HOMA-IR by 35% without medications or complex meal plans. Check blood pressure weekly at home — improvements here often parallel IR reversal. For those managing diabetes, continuous glucose monitors (now available over-the-counter) give real-time feedback on how specific foods affect you personally.

Building Sustainable Habits That Reverse IR Long-Term

Focus on three pillars from the CFP approach: protein-first meals (30g minimum at breakfast), 10-15 minute post-meal walks to blunt glucose spikes, and strength training twice weekly using bodyweight moves that protect joints. These fit busy middle-income schedules without gym memberships insurance won't cover. Expect the first 4-6 weeks to feel revelatory as inflammation drops. Re-test labs at 90 days to confirm progress. The embarrassment of asking for obesity help fades when you see measurable biomarkers improve. Thousands have reversed lifelong patterns this way — you can too by tracking the right things consistently.

💬 What the Community Says

The community is split between those who had the 'aha' moment after decades of yo-yo dieting and others still skeptical that tracking fasting insulin is worth the hassle. Most middle-aged beginners report huge relief discovering IR explained their joint pain, energy crashes, and why low-fat diets failed them. A common theme is frustration with doctors only checking A1C while ignoring fasting insulin levels. Many share success stories of dropping waist inches and feeling less overwhelmed once they started simple glucometer tracking and walking after meals. A vocal minority debates whether CGMs are necessary or just another expense, but lived experiences highlight how seeing real-time glucose responses builds confidence. Insurance barriers and conflicting nutrition advice remain hot topics, yet most agree focusing on HOMA-IR and body measurements feels more empowering than scale weight alone.
Clark, R. (2026). Anyone else come to the realization IR was the root cause of issues throughout y. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/anyone-else-come-to-the-realization-ir-was-the-root-cause-of-issues-throughout-your-life-what-to-track-and-how-to-measure-progress
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ Were any of you guys fans of Journey? How big were they — what the research actually says? ▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what do certified weight loss coaches recommend when you have PCOS or hormonal imbalances? ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients while doing intermittent fasting? 📖 Anti-Inflammatory Protocol — A way of eating that prioritizes whole foods and eliminates triggers to quiet the internal 'fire' that prevents fat cell… ▸ When am I supposed to see a doctor, then and how it connects to gut health and inflammation specifically for women over 40? ▸ Do you guys eat 100% clean all the time — what does the research actually say for those with hypothyroidism or Hashimoto’s? ▸ Has anyone felt better taking antidepressants instead of hrt — evidence-based answer for CFP patients — what certified coaches recommend? ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid specifically for women over 40? 📖 CICO (Calories In, Calories Out) — An outdated model of weight loss that ignores the role of hormones; we challenge this by focusing on food quality and ho… ▸ What’s your favorite toothpaste for people with insulin resistance — what the research actually says? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Why is almost all the focus in treating PCOS on fertility: what to track and how to measure progress while doing intermittent fasting? ▸ Best Curcumin Supplements: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ How long does it take to Is Autophagy? 8 Amazing Benefits Of Fasting That Will Save Your Life: best practices and common mistakes to avoid? ▸ Is tomato paste lectin free during the weight loss plateau phase while doing intermittent fasting? 📖 Amylopectin A — The specific starch found in modern wheat that causes rapid, dangerous spikes in blood glucose and promotes belly fat st… ▸ Can you really Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better on a low-carb or ketogenic diet? ▸ How much protein should I eat if I weigh 280 pounds and want to cut a 100 pounds of fat off of my body? ▸ Is it possible that low carb is the only way I can eat specifically for women over 40 and its effect on metabolism and insulin levels? ▸ Were any of you guys fans of Journey? How big were they when you have PCOS or hormonal imbalances? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ How do you stop the "I already messed up today" spiral and the role of cortisol and stress hormones — what certified coaches recommend? ▸ Omnipod. Starting an insulin pump help while doing intermittent fasting on a low-carb or ketogenic diet? ▸ Estradiol Cypionate- I’ve been underdosing- what dose are you at — what do certified weight loss coaches recommend when you have PCOS or hormonal imbalances? 📖 Autophagy — The body's natural 'housecleaning' process that occurs during fasting or low-insulin states, promoted during our mainten… ▸ Can autophagy regenerate muscle during physically active prolonged fast and how it connects to gut health and inflammation and its effect on metabolism and insulin levels? ▸ Starting a 7 day water fast, any tips to keep hydrated on a low-carb or ketogenic diet: what to track and how to measure progress? ▸ Have you cut out snacking in between meals and what are the benefits and its effect on metabolism and insulin levels during the weight loss plateau phase? ▸ I am on my second week of mounjaro (2.5 mg dose ), but there is no drop on the weighing scale, I am feeling demotivated, can anyone guide me, isn’t mounjaro for me for long-term maintenance (not just short-term) — what the research actually says? ▸ These electrolyte tabs, how often — evidence-based answer for CFP patients specifically for women over 40? ▸ Tips for maintenance: what’s yours for long-term maintenance (not just short-term): best practices and common mistakes to avoid? 📖 Tirzepatide Micro-Dosing — The practice of using the lowest effective dose to achieve results, minimizing side effects while maximizing the longevi… 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Will eating meintenance calories make me lose weight for those with hypothyroidism or Hashimoto's when you have PCOS or hormonal imbalances? ▸ What can I ask for if estrodiol cream remains in shortage? Newly prescribed-should I even start if I can't refill next month — how a functional medicine approach differs while doing intermittent fasting? ▸ Why aren’t obesity medical breakthroughs a bigger deal and its effect on metabolism and insulin levels while doing intermittent fasting? ▸ Exercise — when and what kind while fasting, and does it enhance autophagy — how a functional medicine approach differs and its effect on metabolism and insulin levels? 📖 Visceral Fat — The dangerous 'hidden' fat stored around internal organs that drives chronic disease and is specifically targeted by our… ▸ What foods to stock for overnight guest — evidence-based answer for CFP patients — what certified coaches recommend? ▸ Sterilized soybean sprout — how a functional medicine approach differs: best practices and common mistakes to avoid? ▸ 42yom Im finding it much harder to lose weight, what are some things I can do now to start losing weight? 📖 Nutrient Density — Prioritizing foods that provide maximum vitamins and minerals per calorie to satisfy the brain and end the cycle of hidd… ▸ Is it normal to lose weight then gain again when you have PCOS or hormonal imbalances for long-term maintenance (not just short-term)? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ How much keto-ade should I safely drink: best practices and common mistakes to avoid and how it connects to gut health and inflammation? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for people with insulin resistance? ▸ What is the connection between Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better and its effect on metabolism and insulin levels? ▸ How do you handle social settings and conversations with other people — what does the research actually say on a low-carb or ketogenic diet? ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation and its effect on metabolism and insulin levels? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? 📖 Rebound Weight Gain — The common 'yo-yo' effect caused by high-dose, continuous GLP-1 use; we prevent this through strategic cycling and metab… ▸ When you want something sweet but still try to keep things somewhat low-carb and how it connects to gut health and inflammation on a low-carb or ketogenic diet? ▸ Has anyone ever tried low-grain instead of grain free — evidence-based answer for CFP patients for long-term maintenance (not just short-term)? ▸ Do yall ever daydream of who you were before your diagnosis when you have PCOS or hormonal imbalances if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Diabetics with TPN (IV nutrition experience) and the role of cortisol and stress hormones on a low-carb or ketogenic diet? ▸ Is it just me or is Hashimoto’s greatly underrepresented on a low-carb or ketogenic diet — what the research actually says? ▸ Who still goes to steeplechase — what do certified weight loss coaches recommend for long-term maintenance (not just short-term)? 📖 Non-Scale Victories (NSV) — Improvements in energy, sleep, and disease reversal that matter just as much as the numbers on the scale during your tra… ▸ Anyone remember the metal lid you had to use a butter knife to pop off: what to track and how to measure progress while doing intermittent fasting? ▸ Does drinking Sparkling Ice (flavored sparkling water - 5 calories per bottle) during my fasting window break my fast and the role of cortisol and stress hormones during the weight loss plateau phase? ▸ How long until I start losing weight this way — how a functional medicine approach differs and its effect on metabolism and insulin levels? ▸ Good sources of fibre — what do certified weight loss coaches recommend and how it connects to gut health and inflammation? ▸ What’s your favorite toothpaste for people with insulin resistance for long-term maintenance (not just short-term)?