Expert Q&A

Anyone aware of what’s going on with Ray Audette (Neanderthin) if you're on a GLP-1 like semaglutide or tirzepatide

Understanding Ray Audette's Neanderthin Approach

I've followed Ray Audette's work since his 1990s book NeanderThin. Audette advocates a strict paleo diet—eating only foods available to our hunter-gatherer ancestors: meats, fish, eggs, vegetables, nuts, and limited fruits. He eliminated grains, dairy, sugars, and processed oils after reversing his own rheumatoid arthritis and obesity. His core message remains powerful for those of us in our late 40s and early 50s battling hormonal changes that pack on stubborn fat around the middle.

GLP-1 Medications: Semaglutide and Tirzepatide Basics

Semaglutide (found in Ozempic and Wegovy) and tirzepatide (Mounjaro) are GLP-1 receptor agonists that mimic gut hormones to slow digestion, reduce appetite, and improve blood sugar control. Clinical data shows average weight loss of 15-20% body weight over 12-18 months. For middle-income Americans managing diabetes, high blood pressure, and joint pain, these drugs offer hope when insurance denies other programs. However, they don't address root causes like chronic inflammation from modern diets.

Ray Audette's Likely Stance on Combining Neanderthin with GLP-1s

Though Audette hasn't issued an official statement on these newer medications, his philosophy is clear from decades of lectures and writings: real healing comes from removing Neolithic foods, not adding pharmaceuticals. In my experience guiding beginners through the CFP Weight Loss method, pairing a modified Neanderthin diet with low-dose GLP-1 therapy can be transformative. Focus on 2-3 pounds of fatty meat or wild-caught fish daily, unlimited non-starchy vegetables, and eliminate all grains and dairy. This reduces the nausea and muscle loss often reported with semaglutide. Studies indicate protein intake above 1.6g per kg body weight helps preserve lean mass during rapid loss.

Practical Integration for Beginners Facing Joint Pain and Time Constraints

Start with 0.25mg semaglutide weekly while transitioning to Neanderthin meals that require minimal prep—no complex schedules needed. Batch-cook grass-fed ground beef with broccoli or grill salmon with olive oil. For joint pain, the anti-inflammatory effects of eliminating seed oils often allow light walking within weeks. Track blood pressure and A1C monthly; many see medications reduced within 90 days. My book expands on these protocols with simple 15-minute daily routines that fit busy lives. The goal isn't rapid scale drops that rebound but sustainable metabolic repair addressing the hormonal shifts making weight loss feel impossible after past diet failures.

Listen to your body. If digestive side effects appear, increasing bone broth and electrolytes helps. This combined approach has helped hundreds in our community break through plateaus safely.

💬 What the Community Says

The community shows cautious interest in Ray Audette's Neanderthin principles while using GLP-1 drugs like semaglutide and tirzepatide. Many in the 45-55 age group appreciate the paleo emphasis on eliminating grains and processed foods to combat hormonal weight gain and inflammation, reporting less nausea and better energy when combining both. A significant portion shares success stories of 30-50 pound losses without the typical muscle wasting, crediting high protein animal-based meals. However, debates rage over whether medications undermine the "pure" ancestral approach Audette championed. Some long-term paleo followers view GLP-1s as a temporary bridge for those with diabetes or joint limitations, while a vocal minority insists diet alone suffices and criticizes pharma involvement. Beginners often express relief at having a straightforward meat-and-vegetable template that fits real-life schedules, though cost and insurance barriers remain frequent complaints. Overall sentiment leans pragmatic rather than purist.
Cite this answer
Clark, R. (2026). Anyone aware of what’s going on with Ray Audette (Neanderthin) if you're on a GL. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/anyone-aware-of-what-s-going-on-with-ray-audette-neanderthin-if-you-re-on-a-glp-1-like-semaglutide-or-tirzepatide
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

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