Expert Q&A

Anyone aware of what’s going on with Ray Audette (Neanderthin) during the weight loss plateau phase if you're on a GLP-1 like semaglutide or tirzepatide?

Understanding Plateaus on Tirzepatide and Semaglutide

When patients hit a weight loss plateau while using GLP-1 medications like tirzepatide or semaglutide, the body is often signaling deeper issues. After 35 years in healthcare, I've seen this repeatedly: appetite suppression works initially, but without addressing insulin resistance, lectin-driven inflammation, and toxin burden, progress stalls around weeks 8-12. The scale freezes while joint pain persists and energy stays low. This is exactly why I designed the 30-week protocol in The 30-Week Tirzepatide Reset around three 70-day cycles that combine low-dose cycling with real-food resets.

Ray Audette's Neanderthin Approach in Modern Context

Ray Audette's Neanderthin framework—emphasizing paleolithic-style eating of meats, fats, and non-starchy vegetables while eliminating grains and dairy—aligns closely with our lectin-free foundation. Audette himself navigated metabolic adaptation phases where weight stabilized despite strict adherence. On GLP-1s, this adaptation intensifies because the medications can mask hunger signals without fixing hypothalamic regulation. In our Nashville clinic, we see patients lose 8-15 pounds quickly then plateau. Adding Neanderthin-inspired meals (think grass-fed ribeye, wild salmon, olive oil, and leafy greens) while removing all grains and nightshades breaks the stall. We track this with body-composition apps showing fat loss even when scale weight holds steady for 7-14 days.

Smart Cycling and Root-Cause Tools to Break the Plateau

The biggest mistake is staying on high doses or relying on medication alone. Our protocol uses one box of tirzepatide cycled intelligently across 30 weeks, paired with targeted support. During plateau phases, we activate Detox Drops (Brown formula) to clear liver and lymphatic burden, introduce Japanese-style walking intervals (10 minutes, 3-4 times daily), and incorporate red light therapy sessions. These restore metabolic freedom—the core teaching in my book. Patients also follow chaotic intermittent fasting in maintenance to retrain hunger hormones. Focus on non-scale victories: reduced joint pain, better blood pressure readings (often dropping 10-15 points systolic), and A1C improvements of 1.0-2.0 points. For those managing diabetes alongside weight, this integrated approach prevents rebound gain that occurs in 60-70% of medication-only users.

Real Results and Why This Works Long-Term

Take John, a 58-year-old with similar plateau struggles. At week 10 on tirzepatide his loss halted at 18 pounds. Switching to Neanderthin-aligned lectin-free recipes from our 221-meal plan, adding Detox Drops, and cycling doses per the 69 Transformation Steps melted another 22 pounds by week 20. His joint pain vanished, allowing daily walks without discomfort. Stories like this prove sustainable loss comes from rebuilding your metabolism, not perpetual drug dependence. In The 30-Week Tirzepatide Reset, we teach you to use tirzepatide as a strategic tool while creating the real-food habits that maintain 30-90 pound losses naturally. Start with eliminating ultra-processed carbs and toxins—your body will respond with the healing it was designed for.

💬 What the Community Says

Forum users discussing Ray Audette's Neanderthin during GLP-1 plateaus show a mix of curiosity and practical experimentation. Many in the 45-55 age group report hitting walls around 10-15% body weight lost on tirzepatide or semaglutide, with joint pain making movement difficult and insurance barriers limiting options. A significant portion praises combining paleolithic-style eating with the medications, noting reduced inflammation and renewed progress after cutting grains and lectins. Others debate metabolic adaptation, sharing experiences of stalled scales despite perfect adherence, and express frustration over conflicting advice on cycling doses versus staying on them long-term. Lived stories frequently mention improved energy and blood sugar control when adding walking or detox elements, though a vocal minority worries about sustainability once stopping the injections. Overall sentiment leans toward integrative approaches that blend ancestral eating with modern tools, especially among those who have failed multiple diets before.
Cite this answer
Clark, R. (2026). Anyone aware of what’s going on with Ray Audette (Neanderthin) during the weight. *CFP Weight Loss*. https://ask.cfpweightloss.com/ask/anyone-aware-of-what-s-going-on-with-ray-audette-neanderthin-during-the-weight-loss-plateau-phase-if-you-re-on-a-glp-1-like-semaglutide-or-tirzepatide
Russell Clark, FNP-C, APRN, FNP-C, APRN
About the Author

Russell Clark, FNP-C, APRN, is the founder of CFP Weight Loss in Nashville and CFP Fit Now telehealth. Over 35 years in healthcare — Army Nurse Reserves, Level 1 trauma ER, hospitalist — he developed a 30-week protocol integrating real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 30–90 pounds. He and his wife Anne-Marie lost a combined 275 pounds using the same protocol.

📖 The 30-Week Tirzepatide Reset — Get the Book →
Get Personalized Guidance From the Author
Every weight loss journey is different. Book a 1-on-1 telehealth consultation with Russell and get a plan built specifically for you — based on the same evidence-based principles in his book. Available to patients in all 50 states.
Book Your Consultation →
Have a follow-up question?
More Questions 200 answered
▸ To what extent do Mendelian Randomization Studies provide causal evidence for a particular claim — what does the research actually say specifically for women over 40? ▸ What can I ask for if estrodiol cream remains in shortage? Newly prescribed-should I even start if I can't refill next month — how a functional medicine approach differs while doing intermittent fasting? ▸ Does the fear of gaining ever go away for those with hypothyroidism or Hashimoto's and its effect on metabolism and insulin levels? ▸ Does drinking Sparkling Ice (flavored sparkling water - 5 calories per bottle) during my fasting window break my fast and the role of cortisol and stress hormones during the weight loss plateau phase? ▸ Is anyone else worried about judgment from others for those with hypothyroidism or Hashimoto's if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Caloric Deficit Myth — The false belief that weight loss is purely 'math'; we focus on hormonal signaling rather than just counting calories to… ▸ Crust check 🔥 ribeye done right — what the research actually says? ▸ What is your immediate go to for some relief during ha — what most people get wrong about this — what certified coaches recommend? ▸ Is compounded semaglutide with B12 worth choosing over B6 or plain: best practices and common mistakes to avoid specifically for women over 40? ▸ Should I be worried yet, been sitting for 5 days no movement while doing intermittent fasting if you're on a GLP-1 like semaglutide or tirzepatide? 📖 Maintenance Phase — The final 28 days of our 70-day cycle where we stabilize the new weight and solidify the metabolic habits that prevent f… ▸ How does autophagy only happen whilst we sleep for sustainable results when you have PCOS or hormonal imbalances? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ What can I ask for if estrodiol cream remains in shortage? Newly prescribed-should I even start if I can't refill next month — how a functional medicine approach differs — what the research actually says? ▸ Low TSH, Low T4, and Low T3 simultaneously on Levothyroxine — anyone experienced this and the role of cortisol and stress hormones on a low-carb or ketogenic diet? ▸ How I Lost 22lbs in 3 Months (155→133lbs at 5'8") after not being able to lose weight for a long time if you're on a GLP-1 like semaglutide or tirzepatide during the weight loss plateau phase? ▸ Crust check 🔥 ribeye done right for long-term maintenance (not just short-term)? 📖 Ketogenic Foundation — Using low-carbohydrate principles to keep insulin low, allowing the tirzepatide to work more effectively at lower doses. ▸ If a random dance partner app existed .. would you try it: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ LDN is changing my life, will this last: best practices and common mistakes to avoid: what to track and how to measure progress? ▸ Diabetics with TPN (IV nutrition experience) and the role of cortisol and stress hormones on a low-carb or ketogenic diet? ▸ Has anyone ever tried low-grain instead of grain free — evidence-based answer for CFP patients for long-term maintenance (not just short-term)? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Low TSH, Low T4, and Low T3 simultaneously on Levothyroxine — anyone experienced this and the role of cortisol and stress hormones for those with hypothyroidism or Hashimoto’s? ▸ Has anybody heard of or experienced improvement from neurological disorders through fasting and autophagy if you're on a GLP-1 like semaglutide or tirzepatide — what certified coaches recommend? ▸ What foods to stock for overnight guest — evidence-based answer for CFP patients: what to track and how to measure progress? 📖 Metabolic Reset — The process of retraining your body to utilize stored fat for fuel and regulating hunger hormones so you can maintain yo… ▸ Im eating so well that I accidently put my body in ketosis and how it connects to gut health and inflammation: best practices and common mistakes to avoid? ▸ Fitter or kidding myself: how to talk to your doctor about this if you're on a GLP-1 like semaglutide or tirzepatide? ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances — what the research actually says? ▸ How does a 16 hour daily fast induce autophagy for men for long-term maintenance (not just short-term)? ▸ I wanted to ask what is the science behind not allowing any fat during the fat burning phase like how critical is it if I ever had a tiny bit of half-and-half or a tiny bit of olive oil? Is it really do something to the body. ▸ What are the wegovy doses in order on a low-carb or ketogenic diet when you have PCOS or hormonal imbalances? 📖 Metabolic Flexibility — The body’s ability to efficiently switch between burning carbohydrates and burning stored body fat based on availability… 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ When am I supposed to see a doctor, then and how it connects to gut health and inflammation specifically for women over 40? ▸ Why cant i lose weight and am gaining weight when you have PCOS or hormonal imbalances for those with hypothyroidism or Hashimoto’s? ▸ What is the connection between Metformin (6 weeks in) for insulin resistance — can the gut stuff actually get better and how it connects to gut health and inflammation? ▸ The cost of meat is soaring, especially beef. What are y’all doing to stay on budget on a low-carb or ketogenic diet? ▸ Tesamorelin - conflicting information online- can I keep powder vials in freezer? Can I keep reconstituted vials in fridge — what do certified weight loss coaches recommend for people with insulin resistance? 📖 Bio-Individuality — The understanding that every patient’s metabolic journey is unique, requiring a personalized approach to dosing and diet… ▸ Difference between a 3 day and 5 day water fast for autophagy and the role of cortisol and stress hormones on a low-carb or ketogenic diet? ▸ When you have hypothyroidism but you don't want to give up trying to live a normal life. 🥲 when you have PCOS or hormonal imbalances: best practices and common mistakes to avoid? ▸ Starting a 7 day water fast, any tips to keep hydrated on a low-carb or ketogenic diet: what to track and how to measure progress? ▸ What are the wegovy doses in order on a low-carb or ketogenic diet — what certified coaches recommend? ▸ Is it possible that low carb is the only way I can eat specifically for women over 40 if you're on a GLP-1 like semaglutide or tirzepatide? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Cutting out carbs/sugar completely helps with weight loss and the effects of IR? Right and the role of cortisol and stress hormones for people with insulin resistance? ▸ Does mental health predict diabetes as much as BMI? Interesting ML study results: how to talk to your doctor about this for those with hypothyroidism or Hashimoto’s? 📖 The Clark Protocol — Our evidence-based framework that combines clinical nurse practitioner expertise with personal experience to solve the o… ▸ Is it possible that low carb is the only way I can eat specifically for women over 40 and its effect on metabolism and insulin levels? ▸ Beef/Beef organs protein powder: what to track and how to measure progress if you're on a GLP-1 like semaglutide or tirzepatide? ▸ What’s your favorite toothpaste for people with insulin resistance — what the research actually says? ▸ How many were first diagnosed with OCD if you're on a GLP-1 like semaglutide or tirzepatide on a low-carb or ketogenic diet? ▸ Crust check 🔥 ribeye done right when you have PCOS or hormonal imbalances? 📖 One Box Protocol — A revolutionary approach where we stretch one 60 mg box of tirzepatide across three metabolic phases, prioritizing long-… ▸ Good calorie amount? Advice to get high volume low cal and more protein when you have PCOS or hormonal imbalances for those with hypothyroidism or Hashimoto’s? ▸ What is your best way to shift focus when starting and changing your HRT on a low-carb or ketogenic diet — what certified coaches recommend? ▸ Got diagnosed today, where do i go from here — what do certified weight loss coaches recommend: best practices and common mistakes to avoid? 📗 The 30-Week Tirzepatide Reset — by Russell Clark, FNP-C, APRN · The complete clinical protocol — 30 weeks of real foods, detox, and low-dose tirzepatide cycling that has helped hundreds of patients lose 3 ▸ Is the carnivore diet the best WOE to lose weight — what does the research actually say on a low-carb or ketogenic diet? ▸ Should I be worried yet, been sitting for 5 days no movement while doing intermittent fasting: best practices and common mistakes to avoid? 📖 Hashimoto’s Success — Achieving weight loss and reduced inflammation in thyroid patients by removing dietary triggers like lectins and modern … ▸ Has anyone felt better taking antidepressants instead of hrt — evidence-based answer for CFP patients — what certified coaches recommend?